N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide

Base Information

Chemical Name:N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide
CAS No.:1603902-87-9
Molecular Formula:C₂₅H₂₄ClF₂N₅O₂
Molecular Weight:499.948
Hs Code.:

Synonyms:N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide

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Chemical Property of N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide

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Technology Process of N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide

There total 3 articles about N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1603907-36-3
4-(1-(2-(2, 6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carboxylic acid

: 14763-20-3
3-chlorophenyl hydrazine

: 1603902-87-9
N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1603911-33-6
ethyl 4-(1-(2-(2, 6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carboxylate

: 1603902-87-9
N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium hydroxide; water / 10 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 °C

With methanol; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane;

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 1603902-87-9
N'-(3-chlorophenyl)-4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 5 h / 20 °C

2: methanol; sodium hydroxide; water / 10 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 °C

With methanol; water; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;