14763-20-3

Basic information

• Product Name: (3-chlorophenyl)hydrazine
• Synonyms: Einecs 238-823-4
• CAS NO: 14763-20-3
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.5862
• EINECS: 238-823-4
• Mol File: 14763-20-3.mol
• Article Data: 28

Chemical Properties

• Melting Point: 243 °C
• Boiling Point: 266°C at 760 mmHg
• Flash Point: 114.7°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0.00887mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.91±0.10(Predicted)
• CAS DataBase Reference: (3-chlorophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chlorophenyl)hydrazine(14763-20-3)
• EPA Substance Registry System: (3-chlorophenyl)hydrazine(14763-20-3)

Safety Data

• Hazardous Substances Data: 14763-20-3(Hazardous Substances Data)

Usage

General Description

(3-chlorophenyl)hydrazine is a chemical compound with the formula C6H6ClN2. It is a hydrazine derivative with a chlorophenyl group attached. (3-chlorophenyl)hydrazine is used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also used as a reagent in organic chemistry for the preparation of other compounds. (3-chlorophenyl)hydrazine has been found to exhibit anti-inflammatory and cytotoxic properties and is under investigation for its potential therapeutic applications in cancer treatment. However, it is important to handle this compound with caution due to its hazardous nature and potential health risks.

InChI:InChI=1/C6H7ClN2/c7-5-2-1-3-6(4-5)9-8/h1-4,9H,8H2

Upstream product

• 2312-23-4 m-chlorophenylhydrazine hydrochloride 
• 541-73-1 1,3-Dichlorobenzene 
• 7647-01-0 hydrogenchloride 
• 100-77-6 3-chlorobenzenediazonium chloride 
• 456-39-3 3-chlorobenzenediazonium tetrafluoroborate 
• 108-42-9 3-chloro-aniline 
• 17333-84-5 3-chlorobenzenediazonium 

Downstream Products

• 118305-91-2 1-(3-chloro-phenyl)-4-propyl-pyrazolidine-3,5-dione 
• 108870-85-5 N-(5-chloro-2-nitro-phenyl)-N'-(3-chloro-phenyl)-hydrazine 
• 6463-41-8 1-(m-chlorophenyl)-3-amino-2-pyrazoline 
• 119379-82-7 1,4-bis-(3-chloro-phenyl)-thiosemicarbazide 
• 412339-43-6 2-(3-chlorophenyl)phthalazin-1(2H)-one 
• 109793-46-6 N-(3-Chloro-phenyl)-N'-[1-thiophen-2-yl-eth-(E)-ylidene]-hydrazine 
• 134468-94-3 (3-Chloro-phenyl)-(3,4,6,7,8,9-hexahydro-2H-quinolizin-1-yl)-diazene 
• 76869-92-6 ethyl 2-(3-chlorophenyl)hydrazinecarboxylate 
• 72411-49-5 5-amino-1-(4-chlorophenyl)-3-phenyl-1H-pyrazole 
• 109793-56-8 2-(3-chloro-phenylhydrazono)-propionic acid 
• 109793-50-2 N-(3-Chloro-phenyl)-N'-[1-phenyl-but-(E)-ylidene]-hydrazine 
• 92424-05-0 Acetophenon-(m-chlor-phenylhydrazon) 
• 117664-80-9 3-(4-Chloro-phenyl)-2-[N'-(3-chloro-phenyl)-hydrazinomethyl]-3H-quinazolin-4-one 
• 103973-46-2 deoxybenzoin m-chlorophenylhydrazone 

Relevant articles and documents

Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi

A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC50 values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

Preparation method for 3-chlorophenyl-hydrazine oxalate

The invention relates to a preparation method for 3-chlorophenyl-hydrazine oxalate. The preparation method comprises the steps of diazotization, reduction, purification and salt formation. In the steps of diazotization and reduction, a reaction liquid is maintained strongly acidic by using concentrated hydrochloric acid to ensure smooth and complete reaction. In the step of reduction, zinc powder-concentrated hydrochloric acid is taken as a reducing agent which replaces sodium thiosulfate, sodium hydrogen sulfite, stannous chloride-hydrochloric acid and the like, so that the reducing performance is good, the yield is high, the reaction time is shortened, impurities such as zinc hydroxide generated after reaction are conveniently removed, and the product is few in impurities and high in purity. In the step of salt formation, acetone is used for elution, so that the product purity is improved and the appearance of the product is ensured. The preparation method provided by the invention is stable and reliable in process and easy to operate, and the product purity is high (the content of 3-chlorophenyl-hydrazine oxalate measured by high performance liquid chromatography is greater than or equal to 99%), and the yield is greater than or equal to 42%, and therefore, the demand on 3-chlorophenyl-hydrazine oxalate in the market is fully satisfied.

Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted heteroaromatic pyrazole-containing carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also to a method of using these compounds for treating and/or inhibiting pain and further diseases and/or disorders.