(Z)-3-benzylidene-5-methylphthalide

Base Information

Chemical Name:(Z)-3-benzylidene-5-methylphthalide
CAS No.:959658-87-8
Molecular Formula:C₁₆H₁₂O₂
Molecular Weight:236.27
Hs Code.:

Synonyms:(Z)-3-benzylidene-5-methylphthalide

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Chemical Property of (Z)-3-benzylidene-5-methylphthalide

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Technology Process of (Z)-3-benzylidene-5-methylphthalide

There total 5 articles about (Z)-3-benzylidene-5-methylphthalide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-82-2
phenylacetic acid

: 19438-61-0
4-methylphthalic anhydride

: 959658-87-8
(Z)-3-benzylidene-5-methylphthalide

Guidance literature:: In toluene; at 210 - 245 ℃; Dean-Stark; Inert atmosphere; Alkaline conditions;
DOI:10.1016/j.ejmech.2019.111568

Reference yield:

: 1034421-82-3
2-(2-phenylethynyl)-4-methylbenzaldehyde

: 959658-87-8
(Z)-3-benzylidene-5-methylphthalide

: 6-methyl-3-phenyl-1H-2-benzopyran-1-one

Guidance literature:: With oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride; In acetonitrile; at 80 ℃; for 24h; regioselective reaction;
DOI:10.1021/ol200481u

Reference yield:

: 824-54-4
2-bromo-4-methylbenzaldehyde

: 536-74-3
phenylacetylene

: 959658-87-8
(Z)-3-benzylidene-5-methylphthalide

: 6-methyl-3-phenyl-1H-2-benzopyran-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 50 °C / Inert atmosphere

2: oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride / acetonitrile / 24 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride; In acetonitrile;
DOI:10.1021/ol200481u