β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate

Base Information

Chemical Name:β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate
CAS No.:120637-99-2
Molecular Formula:C₂₄H₃₂N₂O₄
Molecular Weight:412.529
Hs Code.:

Synonyms:β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate

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Chemical Property of β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate

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Technology Process of β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate

There total 9 articles about β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 120637-98-1
BM₀₄₇₁₁

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 120637-99-2
β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate

Guidance literature:: at 120 ℃; for 10h;
DOI:10.1021/jm00127a020

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 120637-99-2
β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / pyridine, KOH / 24 h / 25 °C

2: 1) conc. H₂SO₄, 2) aq. HBr / 1) 80 deg C, 2 h, 2) reflux, 8 h

3: 87 percent / HCl / 16 h

4: 90 percent / H₂ / 5percent Pd/C / aq. ethanol / 24 h / 1810.02 Torr

5: 1) aq. NaNO₂, aq. H₂SO₄ / 1) 0 deg C, 30 min, 2) rt, 72 h

6: 94 percent / aq. KOH / 2 h / 80 °C

7: 1) H₂O, 2) aq. NaHCO₃ / 1) 4 h, 2) ethyl acetate, rt, 36 h, pH 7.8

8: 87 percent / 10 h / 120 °C

With pyridine; hydrogenchloride; potassium hydroxide; sulfuric acid; water; hydrogen bromide; hydrogen; sodium hydrogencarbonate; sodium nitrite; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00127a020

Reference yield:

: 22156-51-0
2-(4-nitrophenyl)-2-phenylpropanenitrile

: 120637-99-2
β-(N,N-Diethylamino)ethyl 2-Phenyl-2-(4-{[(dimethylamino)carbonyl]oxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 7 steps

1: 1) conc. H₂SO₄, 2) aq. HBr / 1) 80 deg C, 2 h, 2) reflux, 8 h

2: 87 percent / HCl / 16 h

3: 90 percent / H₂ / 5percent Pd/C / aq. ethanol / 24 h / 1810.02 Torr

4: 1) aq. NaNO₂, aq. H₂SO₄ / 1) 0 deg C, 30 min, 2) rt, 72 h

5: 94 percent / aq. KOH / 2 h / 80 °C

6: 1) H₂O, 2) aq. NaHCO₃ / 1) 4 h, 2) ethyl acetate, rt, 36 h, pH 7.8

7: 87 percent / 10 h / 120 °C

With hydrogenchloride; potassium hydroxide; sulfuric acid; water; hydrogen bromide; hydrogen; sodium hydrogencarbonate; sodium nitrite; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00127a020