1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine

Base Information

Chemical Name:1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine
CAS No.:1374261-40-1
Molecular Formula:C₂₉H₂₃N₅
Molecular Weight:441.535
Hs Code.:

Synonyms:1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine

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Chemical Property of 1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine

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Technology Process of 1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine

There total 7 articles about 1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1374263-34-9
tert-butyl {1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclopropyl}carbamate

: 1374261-40-1
1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine

Guidance literature:: tert-butyl {1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclopropyl}carbamate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 1374262-87-9
2-phenyl-9H-benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine

: 1374261-40-1
1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 °C

2.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water; ethyl acetate / 18 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 - 20 °C

3.2: NH-silica gel

With potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

: 360773-84-8
tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

: 1374261-40-1
1-[4-(2-phenyl-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclopropanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 5 h / 80 °C

2.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water; ethyl acetate / 18 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 - 20 °C

3.2: NH-silica gel

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;