4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

Base Information

Chemical Name:4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide
CAS No.:351184-43-5
Molecular Formula:C₁₆H₁₉N₃O₃
Molecular Weight:301.345
Hs Code.:

4-cyano-<i>N</i>-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

Synonyms:4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

Chemical Property:

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Technology Process of 4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

There total 2 articles about 4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 351184-43-5
4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / dioxane; H₂O / 1 h / 20 °C

In 1,4-dioxane; water;
DOI:10.1002/jccs.200100024

Reference yield:

: 619-65-8,333406-09-0
4-cyanobenzoic Acid

: 35661-39-3,136132-75-7
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 351184-42-4
9H-fluoren-9-ylmethyl 4-hydroxy-1-piperidinecarboxylate

: 351184-43-5
4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

Guidance literature:: Multistep reaction;
DOI:10.1002/jccs.200100024

Reference yield: 36.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 351184-43-5
4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

: 178601-16-6
{1-[(S)-2-(4-Cyano-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid tert-butyl ester

Guidance literature:: 4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; for 3h; Heating;
DOI:10.1002/jccs.200100024