351184-42-4

Basic information

• Product Name: N-FMOC-4-PIPERIDINOL
• Synonyms: FMOC-4-HYDROXYPIPERIDINE;N-FMOC-4-PIPERIDINOL;4-Hydroxy-1-piperidinecarboxylic acid 9H-fluoren-9-ylmethyl ester
• CAS NO: 351184-42-4
• Molecular Formula: C20H21NO3
• Molecular Weight: 323.39
• Product Categories: pharmacetical
• Mol File: 351184-42-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 510.7 °C at 760 mmHg
• Flash Point: 262.7 °C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 2.97E-11mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• PKA: 14.77±0.20(Predicted)
• CAS DataBase Reference: N-FMOC-4-PIPERIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-FMOC-4-PIPERIDINOL(351184-42-4)
• EPA Substance Registry System: N-FMOC-4-PIPERIDINOL(351184-42-4)

Safety Data

• Hazardous Substances Data: 351184-42-4(Hazardous Substances Data)

Usage

General Description

N-Fmoc-4-piperidinol is a chemical compound that belongs to the family of piperidines. It is commonly used in organic synthesis and pharmaceutical research. The compound is a derivative of piperidine, a six-membered ring containing one nitrogen atom. It is often employed as a building block in the synthesis of various pharmaceuticals and organic compounds due to its reactivity and ability to undergo functional group transformations. N-Fmoc-4-piperidinol is known for its role as a key intermediate in the preparation of fine chemicals and drug candidates.

InChI:InChI=1/C20H21NO3/c22-14-9-11-21(12-10-14)20(23)24-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,14,19,22H,9-13H2

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 1619923-56-6 (R)-1-(3-amino-4-(phenylthio)butyl)piperidin-4-yl di-tert-butyl phosphate 
• 170096-59-0 (1-{2-[4-(N-hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester 
• 172927-65-0 sibrafiban 
• 178740-38-0 (1-{2-[4-(N-hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid 
• 178601-16-6 {1-[(S)-2-(4-Cyano-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid tert-butyl ester 
• 204376-55-6 9H-fluoren-9-ylmethyl 4-oxo-1-piperidinecarboxylate 

Relevant articles and documents

Alcohols immobilization onto 2-chlorotritylchloride resin under microwave irradiation

The immobilization of alcohols onto 2-chlorotritylchloride resin using microwave irradiation was studied. Three different Fmoc-aminoalcohols were tested: the phenol-like Fmoc-tyramine, the primary alcohol Fmoc-ethanolamine, and the secondary alcohol Fmoc-

Mio- and Dio-Fmoc - Two modified Fmoc protecting groups promoting solubility

Two novel Fmoc-derived protecting groups, Mio-Fmoc and Dio-Fmoc, were developed, which cause dramatically enhanced solubility of the corresponding derivatives in most organic solvents. Furthermore, the suitability of these groups in solid-phase peptide synthesis was highlighted. Georg Thieme Verlag Stuttgart.