4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

Base Information

Chemical Name:4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide
CAS No.:1312543-43-3
Molecular Formula:C₂₄H₂₄N₄O₃
Molecular Weight:416.48
Hs Code.:

Synonyms:4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

Chemical Property:

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Technology Process of 4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

There total 6 articles about 4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312543-51-3
2-(3-tert-butylphenylamino)benzo[d]oxazol-5-ol hydrobromide

: 220000-87-3
4-chloro-N-methylpicolinamide

: 1312543-43-3
4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 160 ℃; for 0.416667h; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.04.023

Reference yield:

: 1312543-46-6
N-(3-tert-butylphenyl)-5-methoxybenzo[d]oxazol-2-amine

: 1312543-43-3
4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / 16 h / 100 °C

2: potassium carbonate / dimethyl sulfoxide / 0.42 h / 160 °C / Microwave irradiation

With hydrogen bromide; potassium carbonate; acetic acid; In dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.04.023

Reference yield:

: 49559-83-3
2-mercapto-5-metossi-benzossazolo

: 1312543-43-3
4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl-formamide / 0.5 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 150 °C

3: hydrogen bromide; acetic acid / 16 h / 100 °C

4: potassium carbonate / dimethyl sulfoxide / 0.42 h / 160 °C / Microwave irradiation

With thionyl chloride; hydrogen bromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.04.023