49559-83-3

Basic information

• Product Name: 5-methoxy-3H-benzooxazole-2-thione
• Synonyms: 5-methoxy-3H-benzooxazole-2-thione;2-Mercapto-5-methoxybenzo[d]oxazole, 5-Methoxy-2(3H)-benzoxazolethione;5-Methoxybenzoxazole-2-thiol;5-methoxybenzo[d]oxazole-2(3H)-thione;5-Methoxybenzoxazole-2-thiol 97%;5-methoxy-2(3H)-Benzoxazolethione;Esomeprazole Impurity 8;Omeprazole Impurity 55
• CAS NO: 49559-83-3
• Molecular Formula: C₈H₇NO₂S
• Molecular Weight: 181.21
• Mol File: 49559-83-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 218-223 °C
• Boiling Point: 288.2°Cat760mmHg
• Flash Point: 128.1°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 0.00237mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: 2-8°C
• PKA: 10.92±0.20(Predicted)
• Sensitive: Moisture & Light Sensitive
• CAS DataBase Reference: 5-methoxy-3H-benzooxazole-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-3H-benzooxazole-2-thione(49559-83-3)
• EPA Substance Registry System: 5-methoxy-3H-benzooxazole-2-thione(49559-83-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 49559-83-3(Hazardous Substances Data)

Usage

General Description

5-Methoxy-3H-benzooxazole-2-thione is a chemical compound with the molecular formula C9H7NOS. It is a heterocyclic organic compound containing a benzooxazole ring with a methoxy group attached at the 5-position and a thione functional group at the 2-position. 5-methoxy-3H-benzooxazole-2-thione has potential pharmaceutical and industrial applications due to its unique chemical structure and properties. 5-Methoxy-3H-benzooxazole-2-thione has been studied as a potential antimicrobial and antifungal agent, and it also has potential as a building block in the synthesis of other organic compounds. Additionally, it has been investigated for its potential use in the development of materials with specific electronic or optical properties. Overall, 5-Methoxy-3H-benzooxazole-2-thione is a versatile chemical with a range of potential applications in various fields.

InChI:InChI=1/C8H7NO2S/c1-10-5-2-3-7-6(4-5)9-8(12)11-7/h2-4H,1H3,(H,9,12)

Upstream product

• 140-89-6 potassium ethyl xanthogenate 
• 20734-76-3 2-amino-4-methoxyphenol 
• 67-56-1 methanol 
• 75-15-0 carbon disulfide 
• 1568-70-3 4-methoxy-2-nitrophenol 
• 704-14-3 3-methoxy-6-nitro-phenol 
• 32190-97-9 2-amino-4-methoxyphenol hydrochloride 

Downstream Products

• 49559-34-4 2-chloro-5-methoxybenzo[d]oxazole 
• 1269217-93-7 2-(phenylethynyl)-5-methoxybenzoxazole 
• 1312543-51-3 2-(3-tert-butylphenylamino)benzo[d]oxazol-5-ol hydrobromide 
• 1312543-43-3 4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide 
• 852511-38-7 2-ethylsulfanyl-5-methoxy-benzooxazole 

Relevant articles and documents

OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF

The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceutical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease related to orexin receptors.

Regulatory molecules for the 5-HT3 receptor ion channel gating system

Substituted benzoxazole derivatives which possess a nitrogen-containing heterocycle at C2 are selective partial agonists of the 5-HT3 receptor. Alteration of substituents on the benzoxazole nucleus affords both agonist-like and antagonist-like compounds, and uniquely modifies the function of the 5-HT3 receptor ion channel gating system. SAR and corroborative computational docking study for these partial agonists successfully explained structure and function of the 5-HT3 receptor.

NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.