2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

Base Information

• Chemical Name: 2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine
• CAS No.: 1314535-03-9
• Molecular Formula: C₁₈H₁₂F₃N₃O
• Molecular Weight: 343.308

Synonyms:2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

Chemical Property of 2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

Chemical Property:

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Technology Process of 2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

There total 1 articles about 2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.6%

2-methyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one (1314534-89-8) + propargyl bromide (106-96-7) → 2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine (1314535-03-9) + 2-methyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one (1314534-95-6)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 60 ℃; regioselective reaction;

DOI:10.1016/j.ejmech.2011.05.011

Reference yield: 85.0%

2-methyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine (1314535-03-9) + 1-azido-1H,1H,2H,2H-perfluorodecane (121177-79-5) → 4-((1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-1H-1,2,3-triazol-4yl)methoxy)-2-methyl-7-phenyl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine (1314535-22-2)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.05.011

upstream raw materials:

2-methyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

propargyl bromide

Downstream raw materials:

4-((1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-1H-1,2,3-triazol-4yl)methoxy)-2-methyl-7-phenyl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

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