1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate
• CAS No.: 86688-54-2
• Molecular Formula: C₁₇H₁₄F₆O₄S
• Molecular Weight: 428.352
• Mol file: 86688-54-2.mol

Synonyms:1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate

Chemical Property of 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate

There total 2 articles about 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate (86688-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, I₂ / 1.) ether, reflux; 2.) ether, overnight

2: 1.) KH / 1.) ether; 2.) ether

With iodine; potassium hydride; magnesium;

DOI:10.1021/ja00272a050

Reference yield:

1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol (2093-06-3) + p-toluenesulfonyl chloride (98-59-9) → 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate (86688-54-2)

Guidance literature:

With potassium hydride; Yield given. Multistep reaction; 1.) ether; 2.) ether;

DOI:10.1021/ja00272a050

Reference yield:

1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate (86688-54-2) → 4-cyclohexa-2,5-dienone (16878-48-1)

Guidance literature:

With 2,2,2-trifluoroethanol; water; at 25 ℃;

DOI:10.1021/ja00012a031

upstream raw materials:

1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol

p-toluenesulfonyl chloride

1-bromo-4-methoxy-benzene

Downstream raw materials:

C₁₁H₇⁽²⁾H₃F₆O₂

C₁₁H₄⁽²⁾H₆F₆O₂

1-Methoxy-4-[2,2,2-trifluoro-1-(2,2,2-trifluoro-ethoxy)-1-trifluoromethyl-ethyl]-benzene

4-cyclohexa-2,5-dienone