1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol
• CAS No.: 2093-06-3
• Molecular Formula: C₁₀H₈F₆O₂
• Molecular Weight: 274.163
• Mol file: 2093-06-3.mol

Synonyms:1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol

Chemical Property of 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol

There total 3 articles about 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-bromo-4-methoxy-benzene (104-92-7) + carbon monoxide (201230-82-2) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol (2093-06-3)

Guidance literature:

1-bromo-4-methoxy-benzene; carbon monoxide; With potassium fluoride; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere; Sealed tube;

(trifluoromethyl)trimethylsilane; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201802647

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) + Hexafluoroacetone (684-16-2) → 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol (2093-06-3)

Guidance literature:

With iodine; magnesium; Yield given. Multistep reaction; 1.) ether, reflux; 2.) ether, overnight;

DOI:10.1021/ja00272a050

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) + carbon monoxide (201230-82-2) + (trifluoromethyl)triethylsilane (120120-26-5) → 1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethanol (2093-06-3)

Guidance literature:

1-bromo-4-methoxy-benzene; carbon monoxide; With potassium fluoride; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere; Sealed tube;

(trifluoromethyl)triethylsilane; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Solvent; Reagent/catalyst; Catalytic behavior; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201802647

upstream raw materials:

1-bromo-4-methoxy-benzene

Hexafluoroacetone

carbon monoxide

(trifluoromethyl)trimethylsilane

Downstream raw materials:

1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl bromide

1-(4-methoxyphenyl)-1-(trifluoromethyl)-2,2,2-trifluoroethyl tosylate

1-(1-Ethoxy-2,2,2-trifluoro-1-trifluoromethyl-ethyl)-4-methoxy-benzene

1-Ethoxy-4-(1-ethoxy-2,2,2-trifluoro-1-trifluoromethyl-ethyl)-benzene