AcOH-Gly-Gly-Phe-Leu-O-t-butyl

Base Information

• Chemical Name: AcOH-Gly-Gly-Phe-Leu-O-t-butyl
• CAS No.: 77426-99-4
• Molecular Formula: C₂H₄O₂*C₂₃H₃₆N₄O₅
• Molecular Weight: 508.615
• Mol file: 77426-99-4.mol

Synonyms:AcOH-Gly-Gly-Phe-Leu-O-t-butyl

Chemical Property of AcOH-Gly-Gly-Phe-Leu-O-t-butyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AcOH-Gly-Gly-Phe-Leu-O-t-butyl

There total 3 articles about AcOH-Gly-Gly-Phe-Leu-O-t-butyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Z-Gly-Gly-Phe-Leu-O-t-butyl (77426-95-0) → AcOH-Gly-Gly-Phe-Leu-O-t-butyl (77426-99-4)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol;

DOI:10.1055/s-1980-29275

Reference yield:

L-phenylalanyl-L-leucine tert-butyl ester (28635-78-1) → AcOH-Gly-Gly-Phe-Leu-O-t-butyl (77426-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 2-Methylpropyl carbonochloridate

2: 92 percent / Ammonium formate / 10percent Pd/C / methanol

With ammonium formate; isobutyl chloroformate; palladium on activated charcoal; In methanol;

DOI:10.1055/s-1980-29275

Reference yield:

(S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate (29842-94-2) → AcOH-Gly-Gly-Phe-Leu-O-t-butyl (77426-99-4)

Guidance literature:

Multi-step reaction with 3 steps

1: HCOONH₄/10percent Pd-C and others / relative rates of removal of the benzyoxycarbonyl group

2: 60 percent / 2-Methylpropyl carbonochloridate

3: 92 percent / Ammonium formate / 10percent Pd/C / methanol

With ammonium formate; isobutyl chloroformate; palladium on activated charcoal; 10% palladium on active carbon; ammonium formate; In methanol;

DOI:10.1055/s-1980-29275

upstream raw materials:

Z-Gly-Gly-Phe-Leu-O-t-butyl

L-phenylalanyl-L-leucine tert-butyl ester

(S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

Downstream raw materials:

Boc-Tyr-Gly-Gly-Phe-Leu-OBu^t