Z-Gly-Gly-Phe-Leu-O-t-butyl

Base Information

• Chemical Name: Z-Gly-Gly-Phe-Leu-O-t-butyl
• CAS No.: 77426-95-0
• Molecular Formula: C₃₁H₄₂N₄O₇
• Molecular Weight: 582.697
• Mol file: 77426-95-0.mol

Synonyms:Z-Gly-Gly-Phe-Leu-O-t-butyl

Chemical Property of Z-Gly-Gly-Phe-Leu-O-t-butyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-Gly-Gly-Phe-Leu-O-t-butyl

There total 5 articles about Z-Gly-Gly-Phe-Leu-O-t-butyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

L-leucine tert-butyl ester (21691-53-2) + N-benzyloxycarbonyl-L-glycyl-L-glycyl-L-phenylalanine (13171-93-2) → C31H42N4O7 + Z-Gly-Gly-Phe-Leu-O-t-butyl (77426-95-0)

Guidance literature:

With titanium(IV) dichlorodiisopropylate; 1-(Trimethylsilyl)imidazole; at 50 ℃; for 72h;

Reference yield: 60.0%

CbzGlyGly (2566-19-0) + L-phenylalanyl-L-leucine tert-butyl ester (28635-78-1) → Z-Gly-Gly-Phe-Leu-O-t-butyl (77426-95-0)

Guidance literature:

With isobutyl chloroformate;

DOI:10.1055/s-1980-29275

Reference yield: 58.0%

L-leucine tert-butyl ester (21691-53-2) + N-benzyloxycarbonyl-L-glycyl-L-glycyl-L-phenylalanine (13171-93-2) → Z-Gly-Gly-Phe-Leu-O-t-butyl (77426-95-0)

Guidance literature:

With titanium(IV) isopropylate; 1-(Trimethylsilyl)imidazole; at 50 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.9b03850

upstream raw materials:

CbzGlyGly

L-phenylalanyl-L-leucine tert-butyl ester

(S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

L-leucine tert-butyl ester

Downstream raw materials:

AcOH-Gly-Gly-Phe-Leu-O-t-butyl