N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide

Base Information

Chemical Name:N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide
CAS No.:1430727-65-3
Molecular Formula:C₂₃H₁₆F₂N₄O₄
Molecular Weight:450.401
Hs Code.:

Synonyms:N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide

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Chemical Property of N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide

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Technology Process of N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide

There total 9 articles about N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1-((isocyanomethyl)sulfonyl)-2-methylbenzene

: 1430727-63-1
N-(2',4'-difluoro-5-(4-formyl-2-nitrophenylamino)biphenyl-3-yl)acetamide

: 1430727-65-3
N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide

Guidance literature:: N-(2',4'-difluoro-5-(4-formyl-2-nitrophenylamino)biphenyl-3-yl)acetamide; With potassium carbonate; In methanol; at 20 ℃; for 0.166667h;

1-((isocyanomethyl)sulfonyl)-2-methylbenzene; In methanol; for 4h; Reflux;

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1430727-65-3
N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

2.1: potassium carbonate / methanol / 0.17 h / 20 °C

2.2: 4 h / Reflux

With potassium fluoride; potassium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430727-65-3
N-(2',4'-difluoro-5-(2-nitro-4-(oxazol-5-yl)phenylamino)biphenyl-3-yl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2.1: 0.5 h / 0 - 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5.1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6.1: potassium carbonate / methanol / 0.17 h / 20 °C

6.2: 4 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; palladium 10% on activated carbon; hydrogen; iron; sodium carbonate; potassium carbonate; acetic acid; In methanol; 1,2-dimethoxyethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;