5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine

Base Information

• Chemical Name: 5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine
• CAS No.: 1394921-31-3
• Molecular Formula: C₃₆H₆₂N₄O₅Si₃
• Molecular Weight: 715.169
• Mol file: 1394921-31-3.mol

Synonyms:5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine

Chemical Property of 5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine

There total 2 articles about 5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',3',5'-tri-O-(tert-butyldimethylsilyl)-6-phenyl nebularine N-1 oxide → 5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine (1394921-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: tert.-butylhydroperoxide / tetrachloromethane / 1 h / Reflux

With tert.-butylhydroperoxide; In tetrahydrofuran; tetrachloromethane;

DOI:10.1039/c2cc33511e

Reference yield:

C35H62N4O5Si3 → 5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine (1394921-31-3)

Guidance literature:

With tert.-butylhydroperoxide; In tetrachloromethane; for 1h; Reflux;

DOI:10.1039/c2cc33511e

Reference yield: 94.0%

5-ethyl-8-phenyl-3-[2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3H-imidazo[4,5-d][1,2,6]oxadiazepine (1394921-31-3) → 5-ethyl-8-phenyl-3-(β-D-ribofuranosyl)-3H-imidazo[4,5-d][1,2,6]oxadiazepine (1394921-40-4)

Guidance literature:

With ammonium fluoride; In methanol; for 5h; Reflux;

DOI:10.1039/c2cc33511e

Downstream raw materials:

5-ethyl-8-phenyl-3-(β-D-ribofuranosyl)-3H-imidazo[4,5-d][1,2,6]oxadiazepine