2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

Base Information

Chemical Name:2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline
CAS No.:871583-85-6
Molecular Formula:C₁₇H₁₆BrN₃O₃
Molecular Weight:390.236
Hs Code.:

Synonyms:2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

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Chemical Property of 2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

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Technology Process of 2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

There total 5 articles about 2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 568544-04-7
2-(4-bromophenyl)-5-(chloromethyl)-1,3,4-oxadiazole

: 55414-72-7
(2-amino-5-methoxyphenyl)methanol

: 871583-85-6
2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

Guidance literature:: (2-amino-5-methoxyphenyl)methanol; With sodium hydride; In tetrahydrofuran; at -10 ℃; for 0.75h;

2-(4-bromophenyl)-5-(chloromethyl)-1,3,4-oxadiazole; In tetrahydrofuran; at -10 - 25 ℃; for 1h;

Reference yield:

: 1882-69-5
5-methoxy-2-nitro-benzoic acid

: 871583-85-6
2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 22 h / 0 - 20 °C / Heating / reflux

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / Heating / reflux

3.1: hydrogen / 10% palladium on activated carbon / ethanol; water / 1 h / 3105.31 Torr

4.1: sodium hydride / tetrahydrofuran / 0.75 h / -10 °C

4.2: 1 h / -10 - 25 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride; 10% palladium on activated carbon; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 879-55-0
(5-methoxy-2'-nitrophenyl)methanol

: 871583-85-6
2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / 10% palladium on activated carbon / ethanol; water / 1 h / 3105.31 Torr

2.1: sodium hydride / tetrahydrofuran / 0.75 h / -10 °C

2.2: 1 h / -10 - 25 °C

With hydrogen; sodium hydride; 10% palladium on activated carbon; In tetrahydrofuran; ethanol; water;