2-(4-BROMO-PHENYL)-5-CHLOROMETHYL-[1,3,4]OXADIAZOLE

Base Information

• Chemical Name: 2-(4-BROMO-PHENYL)-5-CHLOROMETHYL-[1,3,4]OXADIAZOLE
• CAS No.: 568544-04-7
• Molecular Formula: C9H6BrClN2O
• Molecular Weight: 273.516
• Hs Code.: 2934999090
• Mol file: 568544-04-7.mol

Synonyms:2-(4-Bromo-phenyl)-5-chloromethyl-[1,3,4]oxadiazole;2-chloromethyl-5-(4-bromophenyl)-1,3,4-oxadiazole;

Chemical Property of 2-(4-BROMO-PHENYL)-5-CHLOROMETHYL-[1,3,4]OXADIAZOLE

Chemical Property:

• PSA: 38.92000
• LogP: 3.23790

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Bromophenyl)-5-(chloromethyl)-1,3,4-oxadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-BROMO-PHENYL)-5-CHLOROMETHYL-[1,3,4]OXADIAZOLE

There total 6 articles about 2-(4-BROMO-PHENYL)-5-CHLOROMETHYL-[1,3,4]OXADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

chloroacetic acid (79-11-8) + 4-bromobenzoic acid hydrazide (5933-32-4) → 2-(4-bromophenyl)-5-(chloromethyl)-1,3,4-oxadiazole (568544-04-7)

Guidance literature:

With trichlorophosphate; for 6h; Reflux;

DOI:10.1016/j.bmcl.2014.09.086

Reference yield: 77.0%

4-bromo-N’-(chloroacetyl)benzohydrazide (199938-23-3) → 2-(4-bromophenyl)-5-(chloromethyl)-1,3,4-oxadiazole (568544-04-7)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 3h;

Reference yield:

4-bromobenzoic acid hydrazide (5933-32-4) → 2-(4-bromophenyl)-5-(chloromethyl)-1,3,4-oxadiazole (568544-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine

2: trichlorophosphate / Reflux

With 4-methyl-morpholine; trichlorophosphate;

DOI:10.1080/00397911003707170

upstream raw materials:

4-bromo-N’-(chloroacetyl)benzohydrazide

4-methoxycarbonylphenyl bromide

4-bromobenzoic acid hydrazide

chloroacetic acid

Downstream raw materials:

2-(4-bromophenyl)-5-(1H-pyrazol-1-ylmethyl)-1,3,4-oxadiazole

2-(4-bromophenyl)-5-(methoxymethyl)-1,3,4-oxadiazole

2-({[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methoxy}methyl)-4-methoxyaniline

benzyl{[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]methyl}[(6-methoxy-3-nitropyridin-2-yl)methyl]amine