(5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

Base Information

Chemical Name:(5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester
CAS No.:78033-36-0
Molecular Formula:C₂₉H₂₆N₂O₇
Molecular Weight:514.535
Hs Code.:

Synonyms:(5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

Suppliers and Price of (5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

There total 4 articles about (5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 78033-35-9
benzyl (4-hydroxymethyl-2-oxo-3-phenylacetamido-1-azetidinyl)malonate

: 78033-36-0
(5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

Guidance literature:: With trifluoromethane sulfonyl chloride; triethylamine; In dichloromethane; at 30 ℃; for 1h;

Reference yield:

: 31661-15-1
dibenzyl aminomalonate

: 78033-36-0
(5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) triethylamine / 1.) methylene dichloride, 6 h, R_.T_.; 2.) methylene dichloride, 5 h

2: 1.) triethylamine, H₂S; 2.) pyridine / 1.) CH₂Cl₂, 0 deg C, 20 min, then 1 h R_.T_.; 2.) 2 h, 25 deg C

3: 76 percent / N₂, O₃, dimethylsulfide, NaBH₄/Al₂O₃ / CH₂Cl₂ / -78 deg C, 16 min, 25 deg C, 2 h

4: 70 percent / trifluoromethanesulfonyl chloride, triethylamine / CH₂Cl₂ / 1 h / 30 °C

With pyridine; aluminum oxide; sodium tetrahydroborate; dimethylsulfide; trifluoromethane sulfonyl chloride; hydrogen sulfide; ozone; triethylamine; In dichloromethane;

Reference yield:

: 2-[(3S,4R)-3-Azido-2-oxo-4-((E)-styryl)-azetidin-1-yl]-malonic acid dibenzyl ester

: 78033-36-0
(5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, H₂S; 2.) pyridine / 1.) CH₂Cl₂, 0 deg C, 20 min, then 1 h R_.T_.; 2.) 2 h, 25 deg C

2: 76 percent / N₂, O₃, dimethylsulfide, NaBH₄/Al₂O₃ / CH₂Cl₂ / -78 deg C, 16 min, 25 deg C, 2 h

3: 70 percent / trifluoromethanesulfonyl chloride, triethylamine / CH₂Cl₂ / 1 h / 30 °C

With pyridine; aluminum oxide; sodium tetrahydroborate; dimethylsulfide; trifluoromethane sulfonyl chloride; hydrogen sulfide; ozone; triethylamine; In dichloromethane;