(2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate

Base Information

Chemical Name:(2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate
CAS No.:294626-19-0
Molecular Formula:C₁₇H₂₄O₆S
Molecular Weight:356.44
Hs Code.:

Synonyms:(2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate

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Chemical Property of (2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate

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Technology Process of (2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate

There total 3 articles about (2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 98-59-9
p-toluenesulfonyl chloride

: 208168-07-4
(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-pentene-1,2-diol

: 294626-19-0
(2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; Heating;
DOI:10.1016/S0040-4039(00)00884-4

Reference yield:

: 147107-70-8
1-O-t-butyldiphenylsilyl-3,4-O-isopropylidene-L-erythrulose

: 294626-19-0
(2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / MgBr₂*Et₂O / CH₂Cl₂ / -40 °C

2: 84 percent / TBAF / tetrahydrofuran / 20 °C

3: 74 percent / NEt₃; DMAP / CH₂Cl₂ / Heating

With dmap; tetrabutyl ammonium fluoride; triethylamine; magnesium bromide; In tetrahydrofuran; dichloromethane; 1: Alkylation / 2: Desilylation / 3: Tosylation;
DOI:10.1016/S0040-4039(00)00884-4

Reference yield:

: 294626-17-8
(2S)-1-O-(tert-butyldiphenylsilyl)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-pentene-1,2-diol

: 294626-19-0
(2S,4'S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxypent-4-enyl p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / TBAF / tetrahydrofuran / 20 °C

2: 74 percent / NEt₃; DMAP / CH₂Cl₂ / Heating

With dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; 1: Desilylation / 2: Tosylation;
DOI:10.1016/S0040-4039(00)00884-4