(2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate

Base Information

• Chemical Name: (2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate
• CAS No.: 1359015-32-9
• Molecular Formula: C₃₅H₄₀N₂O₈S
• Molecular Weight: 648.777

Synonyms:(2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate

Chemical Property of (2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate

Chemical Property:

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Technology Process of (2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate

There total 1 articles about (2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2S,3S)-N-benzyloxycarbonyl-3-methylcysteine methyl ester (858669-61-1) + (R)-β-bromo-N-(fluoren-9-ylmethoxycarbonyl)alanine tert-butyl ester (634182-11-9) → (2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate (1359015-32-9)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; In ethyl acetate; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol203399x DOI:10.1021/ol2034806

Reference yield:

(2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate (1359015-32-9) → C31H32N2O8S

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol203399x

Reference yield:

(2S,3S)-methyl 3-(((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)thio)-2-(((benzyloxy)carbonyl)amino)butanoate (1359015-32-9) → C20H30N2O6S

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ol2034806

upstream raw materials:

(2S,3S)-N-benzyloxycarbonyl-3-methylcysteine methyl ester

(R)-β-bromo-N-(fluoren-9-ylmethoxycarbonyl)alanine tert-butyl ester

Downstream raw materials:

1-O-methyl-3-methyl-7-S-phenyl-(2S,3S,6S)-N₂-(benzyloxycarbonyl)-N₆-(9H-fluoren-9-yl) lanthionate

(5S,6S,Z)-methyl 13-(9H-fluoren-9-yl)-6-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-7-thia-4,10-diazatridec-8-ene-5-carboxylate

(2S,3S)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(((Z)-2-(((benzyloxy)carbonyl)amino)vinyl)thio)butanoate

(2S,3S)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(((E)-2-(((benzyloxy)carbonyl)amino)vinyl)thio)butanoate

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