Technology Process of (5S,6S,Z)-methyl 13-(9H-fluoren-9-yl)-6-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-7-thia-4,10-diazatridec-8-ene-5-carboxylate
There total 5 articles about (5S,6S,Z)-methyl 13-(9H-fluoren-9-yl)-6-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-7-thia-4,10-diazatridec-8-ene-5-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(1,5-cyclooctadiene)nickel (0); copper(I) thiophene-2-carboxylate; triphenylphosphine;
In
1,4-dioxane;
at 50 ℃;
for 3.5h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol203399x
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate / ethyl acetate / 20 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere
3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / ethyl acetate / 20 h / 20 °C / Inert atmosphere
4: copper(I) thiophene-2-carboxylate; bis(1,5-cyclooctadiene)nickel (0); triphenylphosphine / 1,4-dioxane / 3.5 h / 50 °C / Inert atmosphere
With
bis(1,5-cyclooctadiene)nickel (0); copper(I) thiophene-2-carboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/ol203399x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / ethyl acetate / 20 h / 20 °C / Inert atmosphere
2: copper(I) thiophene-2-carboxylate; bis(1,5-cyclooctadiene)nickel (0); triphenylphosphine / 1,4-dioxane / 3.5 h / 50 °C / Inert atmosphere
With
bis(1,5-cyclooctadiene)nickel (0); copper(I) thiophene-2-carboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
1,4-dioxane; ethyl acetate;
DOI:10.1021/ol203399x
