methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate

Base Information

Chemical Name:methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate
CAS No.:130954-90-4
Molecular Formula:C₂₂H₂₀FNO₂
Molecular Weight:349.405
Hs Code.:

Synonyms:methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate

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Technology Process of methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate

There total 4 articles about methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 121659-66-3
4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinecarboxaldehyde

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 130954-90-4
methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate

Guidance literature:: In dichloromethane; for 72h; Ambient temperature;
DOI:10.1021/jm00105a057

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 130954-90-4
methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 28 percent / p-TSA / toluene / 5 h / Heating

2: 94 percent / DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

3: 100 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

4: 74 percent / CH₂Cl₂ / 72 h / Ambient temperature

With oxalyl dichloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; In dichloromethane; toluene;
DOI:10.1021/jm00105a057

Reference yield:

: 3800-06-4
2-amino-4'-fluorobenzophenone

: 130954-90-4
methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 28 percent / p-TSA / toluene / 5 h / Heating

2: 94 percent / DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

3: 100 percent / oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

4: 74 percent / CH₂Cl₂ / 72 h / Ambient temperature

With oxalyl dichloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; In dichloromethane; toluene;
DOI:10.1021/jm00105a057