3800-06-4

Basic information

• Product Name: 2-Amino-4'-fluorobenzophenone
• Synonyms: 2-AMINO-4'-FLUOROBENZOPHENONE;(2-AMINO-4'-FLUORO-PHENYL)-PHENYL-METHANONE;(2-AMINO-PHENYL)-(4-FLUORO-PHENYL)-METHANONE;METHANONE, (2-AMINOPHENYL)(4-FLUOROPHENYL);2-[(4-fluorophenyl)carbonyl]aniline;2-AMinophenyl 4-Fluorophenyl Ketone;o-(p-Fluorobenzoyl)aniline;(2-Aminophenyl)(4-fluorophenyl)methanone, 2-(4-Fluorobenzoyl)aniline
• CAS NO: 3800-06-4
• Molecular Formula: C₁₃H₁₀FNO
• Molecular Weight: 215.22
• EINECS: 1592732-453-0
• Product Categories: Aromatic Benzophenones & Derivatives (substituted);API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pitavastatin Calcium Intermediates
• Mol File: 3800-06-4.mol
• Article Data: 30

Chemical Properties

• Melting Point: 122-128°C
• Boiling Point: 390.559 °C at 760 mmHg
• Flash Point: 190.004 °C
• Appearance: /
• Density: 1.237 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: -0.19±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-4'-fluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4'-fluorobenzophenone(3800-06-4)
• EPA Substance Registry System: 2-Amino-4'-fluorobenzophenone(3800-06-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 3800-06-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

An intermediate in the preparation of the anticholesteremic Pitavastatin.

Upstream product

• 120303-62-0 (4-fluorophenyl)(2-nitrophenyl)methanone 
• 133776-41-7 anthranilic acid N-methoxy-N-methylamide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 610-14-0 2-nitrobenzyl chloride 
• 462-06-6 fluorobenzene 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 51012-30-7 2-(4-Fluoro-benzenesulfonylamino)-benzoic acid 
• 88-72-2 1-methyl-2-nitrobenzene 
• 134-20-3 2-carbomethoxyaniline 
• 352-13-6 4-flourophenylmagnesium bromide 
• 130387-74-5 4-fluorophenylmagnesium chloride 
• 1493-23-8 (4-fluorophenyl)lithium 
• 366-63-2 4-fluoro-N-phenylbenzamide 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 130954-99-3 ethyl 4-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-quinolinecarboxylate 
• 148516-11-4 2-cyclopropyl-4-(4-fluoro-phenyl)-3-quinoline carboxylic acid ethyl ester 
• 449181-29-7 2-cyclopropyl-4-(4'-fluorophenyl)quinoline-3-carbonitrile 
• 827576-95-4 N-[4-({[2-(4-fluorobenzoyl)phenyl]amino}sulfonyl)phenyl]acetamide 
• 872323-67-6 N₂-acetyl-N₁-[2-(4-fluorobenzoyl)phenyl]glycinamide 
• 1229609-91-9 4-(4-fluoro-phenyl)-2-phenyl-quinazoline 
• 1246763-14-3 4-(4'-fluorophenyl)quinazoline 

Relevant articles and documents

Rapid construction of cyclopenta[: B] naphthalene frameworks from propargylic alcohol tethered methylenecyclopropanes

We have developed a new synthetic methodology for the rapid construction of cyclopenta[b]naphthalene frameworks from the reaction of propargylic alcohol tethered methylenecyclopropanes with mesyl chloride in the presence of triethylamine through cascade cyclization. The reaction can be performed under mild conditions without the use of transition metals, affording the target products in moderate to good yields, and this cyclization reaction process can be scaled up to a gram-scale synthesis.

Method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid

Disclosed is a method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid. The method comprises the steps that with 2-arylsulfonamido aromatic carboxylic acid shown in the description as a raw material and triphenylphosphine as a deoxidizer, under the illumination of blue light, in a 1,4-dioxane solution, under an argon atmosphere, in the presence of the dipotassium hydrogenphosphate, with [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as a photocatalyst, the ortho-amino aromatic ketone compound is obtained; the structure of the photocatalyst [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 is shown in thedescription.

Iron-Promoted Construction of Indoles via Intramolecular Oxidative C-N Coupling of 2-Alkenylanilines Using Persulfate

Indole scaffold synthesis relies primarily on oxidative C-H amination of N-protected alkenylanilines for C-N intramolecular cyclization reactions. Herein, for the first time, without N-protection, various readily prepared 2-alkenylanilines were transformed into the desired indole products in good yields by using K 2 S 2 O 8 as oxidant in the presence of catalytic amounts of FeF 2. The K 2 S 2 O 8 /FeF 2 system offers a direct and benign synthetic route to 3-arylindoles and it is applicable to a wide range of substituted indoles including drug intermediates.