(2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine

Base Information

• Chemical Name: (2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine
• CAS No.: 1226778-55-7
• Molecular Formula: C₄₁H₄₄N₂O₇S₂
• Molecular Weight: 740.942
• Mol file: 1226778-55-7.mol

Synonyms:(2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine

Chemical Property of (2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine

There total 1 articles about (2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,4,6-tri-O-benzyl-1,2-dideoxy-1,2-(di-p-toluenesulfonamido)-D-glucitol (1226778-54-6) → (2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine (1226778-55-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/b926123k

Reference yield: 96.0%

(2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine (1226778-55-7) → (2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethylpyrrolidine (1226778-58-0)

Guidance literature:

With disodium hydrogenphosphate; sodium; mercury; In methanol; N,N-dimethyl-formamide; at 60 ℃; for 3h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/b926123k

Reference yield: 95.0%

(2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine (1226778-55-7) + acetic anhydride (108-24-7) → (2S,3R,4R,5S)-2-(N-acetyl-N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine (1226778-57-9)

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃;

DOI:10.1039/b926123k

upstream raw materials:

3,4,6-tri-O-benzyl-1,2-dideoxy-1,2-(di-p-toluenesulfonamido)-D-glucitol

Downstream raw materials:

(2S,3R,4R,5S)-2-(N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethylpyrrolidine

(2S,3R,4R,5S)-2-(N-acetyl-N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine

(2S,3R,4R,5S)-2-(N-ethyl-N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine

(2S,3R,4R,5S)-2-(N-methyl-N-p-toluenesulfonyl)aminomethyl-3,4-dibenzyloxy-5-benzyloxymethyl-1N-(p-tolenesulfonyl)pyrrolidine