(7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine

Base Information

Chemical Name:(7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine
CAS No.:1335447-49-8
Molecular Formula:C₂₉H₃₁ClN₁₀O₄
Molecular Weight:619.083
Hs Code.:

Synonyms:(7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine

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Chemical Property of (7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine

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Technology Process of (7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine

There total 7 articles about (7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1145669-30-2
(2-azidoethyl)-(7-chloro-quinolin-4-yl)amine

: 1335447-88-5
N-(3,5-dimethoxyphenyl)-4-(1-morpholino)-6-(prop-2-ynyloxy)-1,3,5-triazin-2-amine

: 1335447-49-8
(7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 40 ℃; for 3h;
DOI:10.1111/j.1747-0285.2011.01115.x

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 1335447-49-8
(7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 5 °C

2: potassium carbonate / tetrahydrofuran / 20 °C

3: tetrahydrofuran / 4 h / 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 3 h / 40 °C

With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; potassium carbonate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1111/j.1747-0285.2011.01115.x

Reference yield:

: 852402-04-1
methanesulfonic acid 2-(7-chloro-quinolin-4-ylamino)ethyl ester

: 1335447-49-8
(7-chloroquinolin-4-yl)-(2-{4-[(4-(3,5-dimethoxyphenylamino)-6-(morpholin-4-yl)-[1,3,5]triazin-2-yl)oxymethyl]-[1,2,3]triazol-1-yl}ethyl)amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 50 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 3 h / 40 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1111/j.1747-0285.2011.01115.x