N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline

Base Information

Chemical Name:N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline
CAS No.:121374-72-9
Molecular Formula:C₂₀H₂₆N₂O₄
Molecular Weight:358.437
Hs Code.:

Synonyms:N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline

Chemical Property:

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Technology Process of N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline

There total 6 articles about N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 121374-71-8
N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-p-nitroaniline

: 74-88-4
methyl iodide

: 121374-72-9
N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1021/jo00275a034

Reference yield:

: 40614-20-8
3-(2'-Hydroxyphenyl)-3,3-dimethylpropanol

: 121374-72-9
N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / sodium hydride / tetrahydrofuran / 6 h / 0 - 20 °C

2: 100 percent / pyridine / 18 h / 4 °C

3: 90 percent / dimethylformamide / 18 h / 60 °C

4: 100 percent / 85percent hydrazine hydrate / aq. ethanol / 18 h / Heating

5: 22 percent / potassium carbonate / acetonitrile / 18 h / Heating

6: 66 percent / sodium hydride / tetrahydrofuran / 18 h / Ambient temperature

With pyridine; sodium hydride; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00275a034

Reference yield:

: 121374-67-2
3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propanol

: 121374-72-9
N-<3-<2-O-(methoxymethyl)-2-hydroxyphenyl>-3,3-dimethyl-1-propyl>-N-methyl-p-nitroaniline

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / pyridine / 18 h / 4 °C

2: 90 percent / dimethylformamide / 18 h / 60 °C

3: 100 percent / 85percent hydrazine hydrate / aq. ethanol / 18 h / Heating

4: 22 percent / potassium carbonate / acetonitrile / 18 h / Heating

5: 66 percent / sodium hydride / tetrahydrofuran / 18 h / Ambient temperature

With pyridine; sodium hydride; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00275a034