(4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

Base Information

Chemical Name:(4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline
CAS No.:131484-13-4
Molecular Formula:C₂₃H₂₇NO₃
Molecular Weight:365.472
Hs Code.:

(4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzo<f>quinoline

Synonyms:(4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

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Chemical Property of (4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

Chemical Property:

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Technology Process of (4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

There total 6 articles about (4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 34713-98-9
(R)-(-)-α-methoxyphenylacetyl chloride

: 82171-89-9,109062-18-2,109062-19-3,131484-11-2,131484-14-5
trans-10-methoxy-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline

: 131484-13-4
(4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

: 131484-12-3
(4aR,10bR,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

Guidance literature:: With sodium hydroxide; In dichloromethane; for 1.5h;
DOI:10.1021/jm00106a004

Reference yield:

: 82171-81-1
1,4,5,6-tetrahydro-10-methoxybenzoquinolin-3-(2H)-one

: 131484-13-4
(4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: SiHEt₃, CF₃COOH / CH₂Cl₂ / 65 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 20 h / Heating

3: 13 percent / K₂CO₃ / acetonitrile / 72 h / Ambient temperature

4: H₂ / 10percent Pd/C / methanol / 735.5 Torr

5: 1 M aq. NaOH / CH₂Cl₂ / 1.5 h

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00106a004

Reference yield:

: 908095-63-6
10-Methoxy-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one

: 131484-13-4
(4aS,10bS,αR)-1,2,3,4,4a,5,6,10b-otahydro-10-methoxy-4-(α-methoxy-α-phenylacetyl)benzoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 20 h / Heating

2: 13 percent / K₂CO₃ / acetonitrile / 72 h / Ambient temperature

3: H₂ / 10percent Pd/C / methanol / 735.5 Torr

4: 1 M aq. NaOH / CH₂Cl₂ / 1.5 h

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00106a004