(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

Base Information

Chemical Name:(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate
CAS No.:432515-20-3
Molecular Formula:C₂₀H₂₂F₃NO₅S
Molecular Weight:445.46
Hs Code.:

Synonyms:(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

Chemical Property:

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Technology Process of (S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

There total 1 articles about (S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 16874-12-7,87553-74-0
Tyr(tBu)

: 432515-20-3
(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

Guidance literature:: 3-(Trifluoromethyl)benzenesulfonyl chloride; Tyr(tBu); In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;

With sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h; optical yield given as %ee;
DOI:10.1021/jm901133z

Reference yield: 98.0%

: 432515-20-3
(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

: 432515-23-6
t-butyl (S)-3-(4-hydroxy-3-nitrophenyl)-2-(3-trifluoromethyl-1-benzenesulfonylamino)-propionate

Guidance literature:: With nitric acid; In acetic acid; at 15 - 19 ℃; for 1.25h; optical yield given as %ee;
DOI:10.1021/jm901133z

Reference yield:

: 432515-20-3
(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

: 798567-33-6
(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / acetic acid; nitric acid / 16 - 20 °C

2: 56 percent / K₂CO₃; 18-crown-6 / acetonitrile / 22 h / Heating

3: H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C / 2068.59 Torr

With 18-crown-6 ether; hydrogen; nitric acid; potassium carbonate; acetic acid; platinum(IV) oxide; In ethyl acetate; acetonitrile; 2: Williamson reaction;
DOI:10.1016/j.bmc.2004.07.055