(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

Base Information

Chemical Name:(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate
CAS No.:798567-33-6
Molecular Formula:C₂₈H₃₈F₃N₃O₇S
Molecular Weight:617.687
Hs Code.:

Synonyms:(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

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Chemical Property of (S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

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Technology Process of (S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

There total 4 articles about (S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 798567-32-5
(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-nitrophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

: 798567-33-6
(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; under 750.075 Torr;
DOI:10.1021/jm901133z

Reference yield:

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 798567-33-6
(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / pyridine / CH₂Cl₂ / 5 h / 20 °C

2: 95 percent / acetic acid; nitric acid / 16 - 20 °C

3: 56 percent / K₂CO₃; 18-crown-6 / acetonitrile / 22 h / Heating

4: H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C / 2068.59 Torr

With pyridine; 18-crown-6 ether; hydrogen; nitric acid; potassium carbonate; acetic acid; platinum(IV) oxide; In dichloromethane; ethyl acetate; acetonitrile; 3: Williamson reaction;
DOI:10.1016/j.bmc.2004.07.055

Reference yield:

: 432515-20-3
(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

: 798567-33-6
(S)-t-butyl 3-(4-(3-t-butoxycarbonylaminopropoxy)-3-aminophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / acetic acid; nitric acid / 16 - 20 °C

2: 56 percent / K₂CO₃; 18-crown-6 / acetonitrile / 22 h / Heating

3: H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C / 2068.59 Torr

With 18-crown-6 ether; hydrogen; nitric acid; potassium carbonate; acetic acid; platinum(IV) oxide; In ethyl acetate; acetonitrile; 2: Williamson reaction;
DOI:10.1016/j.bmc.2004.07.055