1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea

Base Information

Chemical Name:1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea
CAS No.:1334523-35-1
Molecular Formula:C₂₅H₂₁Cl₂FN₄O₄S
Molecular Weight:563.437
Hs Code.:

Synonyms:1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea

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Chemical Property of 1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea

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Technology Process of 1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea

There total 5 articles about 1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.3%

: 1334523-88-4
3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

: 404-71-7
1-fluoro-3-isocyanatobenzene

: 1334523-35-1
1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea

Guidance literature:: With triethylamine; In dichloromethane; for 3h;

Reference yield:

: 942199-56-6
2-chloro-5-cyanobenzene-1-sulfonyl chloride

: 1334523-35-1
1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C

2.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 96 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 22 h

3.2: pH 7

4.1: triethylamine / dichloromethane / 3 h

With 18-crown-6 ether; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1334523-87-3
C₂₃H₂₅Cl₂N₃O₅S

: 1334523-35-1
1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 22 h

1.2: pH 7

2.1: triethylamine / dichloromethane / 3 h

With triethylamine; trifluoroacetic acid; In dichloromethane;