3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

Base Information

Chemical Name:3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile
CAS No.:1334523-88-4
Molecular Formula:C₁₈H₁₇Cl₂N₃O₃S
Molecular Weight:426.323
Hs Code.:

Synonyms:3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

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Chemical Property of 3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

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Technology Process of 3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

There total 4 articles about 3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1334523-87-3
C₂₃H₂₅Cl₂N₃O₅S

: 1334523-88-4
3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

Guidance literature:: C₂₃H₂₅Cl₂N₃O₅S; With trifluoroacetic acid; In dichloromethane; for 22h;

With sodium hydroxide; pH=7;

Reference yield:

: 942199-56-6
2-chloro-5-cyanobenzene-1-sulfonyl chloride

: 1334523-88-4
3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C

2.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 96 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 22 h

3.2: pH 7

With 18-crown-6 ether; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1334523-88-4
3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C

2.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 96 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 22 h

3.2: pH 7

With 18-crown-6 ether; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;