C₃₁H₄₀F₃N₅O₄

Base Information

Chemical Name:C₃₁H₄₀F₃N₅O₄
CAS No.:1416328-86-3
Molecular Formula:C₃₁H₄₀F₃N₅O₄
Molecular Weight:603.685
Hs Code.:

C<sub>31</sub>H<sub>40</sub>F<sub>3</sub>N<sub>5</sub>O<sub>4</sub>

Synonyms:C₃₁H₄₀F₃N₅O₄

Suppliers and Price of C₃₁H₄₀F₃N₅O₄

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₃₁H₄₀F₃N₅O₄

Chemical Property:

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Technology Process of C₃₁H₄₀F₃N₅O₄

There total 18 articles about C₃₁H₄₀F₃N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312590-10-5
C₁₃H₁₆F₃NO

: 1416329-83-3
C₁₈H₂₅ClN₄O₃

: 1416328-86-3
C₃₁H₄₀F₃N₅O₄

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 120 ℃; for 1h; Microwave vial;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1416328-86-3
C₃₁H₄₀F₃N₅O₄

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 18 h / 0 - 20 °C

3: triethylammonium formate / N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium / 18 h / 70 °C / Inert atmosphere

4: sodium hydrogencarbonate; iodine / acetonitrile / 1 h / 20 °C

5: N,N-dimethyl-formamide / 18 h / 90 °C

6: ethanolamine / toluene / 3 h / 70 °C

7: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 120 °C / Microwave vial

With iodine; triethylammonium formate; sodium hydrogencarbonate; potassium carbonate; ethanolamine; N-ethyl-N,N-diisopropylamine; N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1159010-94-2
6-hydroxy-5-methyl-pyrimidine-4-carboxylic acid

: 1416328-86-3
C₃₁H₄₀F₃N₅O₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere

2.2: 18 h / 0 - 20 °C

3.1: DAICEL Chiralpack AD-H / isopropyl alcohol; hexane / Resolution of racemate

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 120 °C / Microwave vial

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; isopropyl alcohol;