diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

Base Information

Chemical Name:diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate
CAS No.:1345983-91-6
Molecular Formula:C₂₇H₄₀NO₆PS
Molecular Weight:537.657
Hs Code.:

Synonyms:diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

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Chemical Property of diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

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Technology Process of diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

There total 12 articles about diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1510807-76-7
diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]-thiazepin-8-yl)methyl)phosphonate

: 1345983-91-6
diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

Guidance literature:: With dihydrogen peroxide; trifluoroacetic acid; at -20 - 20 ℃; for 40.5h;
DOI:10.1021/jo402311e

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7,8-dimethoxy-5-phenyl-1-4-benzothiazepine-1,1-dioxide

: 1345983-91-6
diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 25 °C

2.1: pyridine / dichloromethane / 0 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / N,N-dimethyl-formamide / 0.25 h

3.2: 70 °C

4.1: diisobutylaluminium hydride / toluene / 1.5 h / 0 - 25 °C / Inert atmosphere

5.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C

6.1: toluene

With pyridine; 1H-imidazole; hydrogenchloride; aluminum (III) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400459m

Reference yield:

: 1345983-39-2
(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl trifluoromethanesulfonate

: 1345983-91-6
diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / N,N-dimethyl-formamide / 0.25 h

1.2: 70 °C

2.1: diisobutylaluminium hydride / toluene / 1.5 h / 0 - 25 °C / Inert atmosphere

3.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C

4.1: toluene

With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400459m