{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt

Base Information

Chemical Name:{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt
CAS No.:1345982-39-9
Molecular Formula:C₂₃H₃₂NO₆PS*ClH
Molecular Weight:518.011
Hs Code.:

Synonyms:{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt

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Chemical Property of {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt

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Technology Process of {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt

There total 11 articles about {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1345983-91-6
diethyl (((3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f ][1,4]thiazepin-8-yl)methyl)phosphonate

: 1345982-39-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt

Guidance literature:: With hydrogenchloride; at 120 ℃; for 20h; Sealed tube;
DOI:10.1021/jo402311e

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7,8-dimethoxy-5-phenyl-1-4-benzothiazepine-1,1-dioxide

: 1345982-39-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 25 °C

2.1: pyridine / dichloromethane / 0 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / N,N-dimethyl-formamide / 0.25 h

3.2: 70 °C

4.1: diisobutylaluminium hydride / toluene / 1.5 h / 0 - 25 °C / Inert atmosphere

5.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C

6.1: toluene

7.1: hydrogenchloride / ethanol; water

With pyridine; 1H-imidazole; hydrogenchloride; aluminum (III) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400459m

Reference yield:

: 1345983-42-7
[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

: 1345982-39-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}phosphonic acid hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C

2: toluene

3: hydrogenchloride / ethanol; water

With 1H-imidazole; hydrogenchloride; bromine; triphenylphosphine; In ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm400459m