3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Base Information

Chemical Name:3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide
CAS No.:1374454-05-3
Molecular Formula:C₂₇H₂₆ClN₅O₅
Molecular Weight:535.987
Hs Code.:

3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Synonyms:3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Suppliers and Price of 3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

There total 8 articles about 3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1374454-06-4
3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1374454-05-3
3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 38343-91-8
3-chloro-1H-indole-2-carboxylic acid ethyl ester

: 1374454-05-3
3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve

2.1: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / 20 °C

3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 20 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

5.2: pH 5

6.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; copper diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 1374454-05-3
3-chloro-1-{4-[({1-[(3-methoxy-isoxazole-5-carbonyl)-amino]-cyclopropane-carbonyl}-amino)-methyl]-phenyl}-1H-indole-2-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / acetonitrile / 20 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve

3.1: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / 20 °C

4.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 20 °C

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

6.2: pH 5

7.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; copper diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;