3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene

Base Information

Chemical Name:3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene
CAS No.:1610422-58-6
Molecular Formula:C₂₅H₁₇F₇O₂
Molecular Weight:482.398
Hs Code.:

Synonyms:3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene

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Chemical Property of 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene

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Technology Process of 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene

There total 3 articles about 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1610422-55-3
2-(4-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy))-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 1610422-58-6
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene

Guidance literature:: 2-(4-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy))-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one; 4-methoxyphenyl magnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 12h; Inert atmosphere; Reflux;

With hydrogenchloride; In ethanol; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/jm500569h

Reference yield:

: 3470-51-7
2-hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one

: 1610422-58-6
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere

2.1: diethyl ether; tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Reflux

2.2: 2 h / Inert atmosphere; Reflux

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jm500569h

Reference yield:

: 6500-65-8
2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

: 1610422-58-6
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / toluene / Reflux

2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere

3.1: diethyl ether; tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Reflux

3.2: 2 h / Inert atmosphere; Reflux

With aluminum (III) chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/jm500569h