(R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester

Base Information

• Chemical Name: (R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester
• CAS No.: 851795-78-3
• Molecular Formula: C₁₄H₂₆O₃
• Molecular Weight: 242.359
• Mol file: 851795-78-3.mol

Synonyms:(R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester

Chemical Property of (R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester

There total 1 articles about (R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohexyl iodide (626-62-0) + tert-butyl 2-hydroxymethylacrylate (121065-74-5) → (S)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester + (R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester (851795-78-3)

Guidance literature:

tert-butyl 2-hydroxymethylacrylate; With chiral 1,1-bis(2-oxazolin-2-yl)cylopropyl-derived ligand; magnesium iodide; In dichloromethane; at -78 ℃; for 0.5h;

Cyclohexyl iodide; With oxygen; tri-n-butyl-tin hydride; In hexane; dichloromethane; at -78 ℃; for 3h; Title compound not separated from byproducts;

DOI:10.1021/ol047347h

Reference yield: 80.0%

(R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester (851795-78-3) → (R)-3-Cyclohexyl-2-hydroxymethyl-propionic acid

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ol047347h

Reference yield:

(R)-3-cyclohexyl-2-hydroxymethyl-propionic acid tert-butyl ester (851795-78-3) → (R)-3-cyclohexyl-2-hydroxymethyl-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / TFA / CH₂Cl₂

2: 78 percent / methanol / 1 h / 0 °C

With trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/ol047347h

upstream raw materials:

Cyclohexyl iodide

tert-butyl 2-hydroxymethylacrylate