4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate

Base Information

• Chemical Name: 4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate
• CAS No.: 1380545-64-1
• Molecular Formula: C₇H₁₀N₂*C₂₀H₁₄ClN₃O₄S₃
• Molecular Weight: 614.17
• Mol file: 1380545-64-1.mol

Synonyms:4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate

Chemical Property of 4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate

There total 3 articles about 4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-thiophenylcarboxylic acid (527-72-0) + dmap (1122-58-3) + 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide (1380545-54-9) → 4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate (1380545-64-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃;

DOI:10.1007/s00706-012-0732-6

Reference yield:

2,4-dichloro-5-(carbazoyl)benzenesulfonamide (18648-15-2) → 4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate (1380545-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / Reflux

2: tetrabutylammomium bromide; potassium carbonate / water; acetonitrile / 24 h / 25 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C

With tetrabutylammomium bromide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; acetic acid; acetonitrile;

DOI:10.1007/s00706-012-0732-6

Reference yield:

2,4-dichloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide (1380545-52-7) → 4-(N,N-dimethylamino)pyridinium 2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamidate (1380545-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate / water; acetonitrile / 24 h / 25 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C

With tetrabutylammomium bromide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; acetonitrile;

DOI:10.1007/s00706-012-0732-6

upstream raw materials:

2-thiophenylcarboxylic acid

dmap

2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide

2,4-dichloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide

Downstream raw materials:

2-benzylthio-4-chloro-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamide