2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Base Information

Chemical Name:2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol
CAS No.:312732-08-4
Molecular Formula:C₂₅H₃₇NO₇Si
Molecular Weight:491.657
Hs Code.:

2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-propan-1-ol

Synonyms:2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Suppliers and Price of 2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

There total 9 articles about 2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 312732-24-4
acetic acid 2(R)-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester

: 312732-08-4
2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 1h;
DOI:10.1021/ja0013879

Reference yield:

: 6635-20-7
isonitrovanillin

: 312732-08-4
2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / HBr; AcOH / H₂O / 8 h / Heating

2: 85 percent / NaH / dimethylformamide

3: 95 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

4: 80 percent / dimethylformamide / 1 h

5: 96 percent / TsOH / methanol / 3 h / Heating

6: 49 percent / DIBAL-H / toluene / 0.83 h / 0 - 20 °C

7: Pseudomonas species lipase; 4A sieve / 18 h / 35 °C

8: 82 percent / imidazole / dimethylformamide / 18 h / 20 °C

9: 55 percent / K₂CO₃ / methanol / 1 h / 20 °C

With pyridine; 1H-imidazole; 4 A molecular sieve; Pseudomonas species lipase; hydrogen bromide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja0013879

Reference yield:

: 116313-85-0
3,4-dihydroxy-5-nitrobenzaldehyde

: 312732-08-4
2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / NaH / dimethylformamide

2: 95 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

3: 80 percent / dimethylformamide / 1 h

4: 96 percent / TsOH / methanol / 3 h / Heating

5: 49 percent / DIBAL-H / toluene / 0.83 h / 0 - 20 °C

6: Pseudomonas species lipase; 4A sieve / 18 h / 35 °C

7: 82 percent / imidazole / dimethylformamide / 18 h / 20 °C

8: 55 percent / K₂CO₃ / methanol / 1 h / 20 °C

With pyridine; 1H-imidazole; 4 A molecular sieve; Pseudomonas species lipase; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja0013879