3-Benzyloxy-4-hydroxy-5-nitro-benzaldehyde

Base Information

• Chemical Name: 3-Benzyloxy-4-hydroxy-5-nitro-benzaldehyde
• CAS No.: 312327-13-2
• Molecular Formula: C14H11NO5
• Molecular Weight: 273.245
• Hs Code.: 2913000090
• Mol file: 312327-13-2.mol

Synonyms:3-Benzyloxy-4-hydroxy-5-nitro-benzaldehyde;Benzaldehyde, 4-hydroxy-3-nitro-5-(phenylmethoxy)-

Chemical Property of 3-Benzyloxy-4-hydroxy-5-nitro-benzaldehyde

Chemical Property:

• PSA: 92.35000
• LogP: 3.21510

Purity/Quality:

97% ^*data from raw suppliers

3-(Benzyloxy)-4-hydroxy-5-nitrobenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzyloxy-4-hydroxy-5-nitro-benzaldehyde

There total 2 articles about 3-Benzyloxy-4-hydroxy-5-nitro-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,4-dihydroxy-5-nitrobenzaldehyde (116313-85-0) + benzyl bromide (100-39-0) → 3-benzyloxy-4-hydroxy-5-nitro-benzaldehyde (312327-13-2)

Guidance literature:

In N,N-dimethyl-formamide; at 140 ℃; for 48h;

DOI:10.1021/jo001080s

Reference yield:

isonitrovanillin (6635-20-7) → 3-benzyloxy-4-hydroxy-5-nitro-benzaldehyde (312327-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / HBr; AcOH / H₂O / 8 h / Heating

2: 85 percent / NaH / dimethylformamide

With hydrogen bromide; sodium hydride; acetic acid; In water; N,N-dimethyl-formamide;

DOI:10.1021/ja0013879

Reference yield: 95.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-benzyloxy-4-hydroxy-5-nitro-benzaldehyde (312327-13-2) → trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester (312731-70-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja0013879

upstream raw materials:

3,4-dihydroxy-5-nitrobenzaldehyde

benzyl bromide

isonitrovanillin

Downstream raw materials:

3-benzyloxy-4-methoxy-5-nitrobenzaldehyde

trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-acetoxy-2-(2-benzyloxy-4-hydroxymethyl-6-nitro-phenyl)-propyl ester

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-acetoxy-2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-propyl ester