(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile

Base Information

Chemical Name:(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile
CAS No.:50345-02-3
Molecular Formula:C₂₉H₂₉NO₃
Molecular Weight:439.554
Hs Code.:

Synonyms:(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile

Chemical Property:

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Technology Process of (1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile

There total 10 articles about (1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 201208-25-5
(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarboxamide

: 50345-02-3
(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile

Guidance literature:: With pyridine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1080/15257779908043088

Reference yield:

: N'-[1-((3aS,4S,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-meth-(E)-ylidene]-N,N-dimethyl-hydrazine

: 50345-02-3
(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile

Guidance literature:: With magnesium monoperoxyphthalate hexahydrate; In methanol; at 0 ℃; for 0.166667h;
DOI:10.1080/15257779908043088

Reference yield:

: 85026-58-0
(1R,5R,6R,7S)-6,7-(isopropylidenedioxy)-3-oxabicyclo[3.2.1]octane-2-one

: 50345-02-3
(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: NH₃ / methanol / 20 °C

2: 69.81 g / Et₃N; DMAP / acetonitrile / 4 h / 20 °C

3: 99.5 percent / trifluoroacetic anhydride; pyridine / tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; dmap; ammonia; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; acetonitrile; 1: Ring cleavage / 2: Etherification / 3: Dehydration;
DOI:10.1080/15257779908043088