Technology Process of 5-[(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentyl]-1H-tetrazole
There total 10 articles about 5-[(1S,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)cyclopentyl]-1H-tetrazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium azide; pyridinium trifluroacetate;
In
pyridine;
at 120 ℃;
for 4h;
DOI:10.1080/15257779908043088
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NH3 / methanol / 20 °C
2: 69.81 g / Et3N; DMAP / acetonitrile / 4 h / 20 °C
3: 99.5 percent / trifluoroacetic anhydride; pyridine / tetrahydrofuran / 2 h / 0 - 20 °C
4: 77 percent / lithium azide; pyridinium trifluoroacetate / pyridine / 4 h / 120 °C
With
pyridine; dmap; lithium azide; ammonia; pyridinium trifluroacetate; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran; pyridine; methanol; acetonitrile;
1: Ring cleavage / 2: Etherification / 3: Dehydration / 4: Cycloaddition;
DOI:10.1080/15257779908043088
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Et3N; DMAP / 1,2-dichloro-ethane / 4 h / 60 °C
2: 149.25 g / K2CO3 / methanol / 5 h
3: pyridinium chlorochromate; sodium acetate / CH2Cl2 / 4 h / 20 °C
4: methanol / 2 h
5: 4.54 g / magnesium monoperoxyphthalate hexahydrate / methanol / 0.17 h / 0 °C
6: 77 percent / lithium azide; pyridinium trifluoroacetate / pyridine / 4 h / 120 °C
With
dmap; lithium azide; sodium acetate; pyridinium trifluroacetate; potassium carbonate; magnesium monoperoxyphthalate hexahydrate; triethylamine; pyridinium chlorochromate;
In
pyridine; methanol; dichloromethane; 1,2-dichloro-ethane;
1: Etherification / 2: deacylation / 3: Oxidation / 4: Condensation / 5: Elimination / 6: Cycloaddition;
DOI:10.1080/15257779908043088
