Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

Base Information

Chemical Name:Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate
CAS No.:1246246-82-1
Molecular Formula:C₂₅H₃₄N₄O₅
Molecular Weight:470.569
Hs Code.:

Synonyms:Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

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Chemical Property of Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

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Technology Process of Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

There total 6 articles about Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1246246-81-0
Benzyl {3-[({5-[(tert-butoxycarbonyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

: 74-88-4
methyl iodide

: 1246246-82-1
Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

Guidance literature:: Benzyl {3-[({5-[(tert-butoxycarbonyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h; Cooling with ice;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1246246-82-1
Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

1.2: 20 °C / Cooling with ice

1.3: 2 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / methanol / 10 h / 50 °C

2.2: pH 3

3.1: triethylamine; diphenyl phosphoryl azide / 3 h / Reflux

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C / Cooling with ice

4.2: 20 °C

With diphenyl phosphoryl azide; water; pivaloyl chloride; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 111-33-1
1,3-bis(methylamino)propane

: 1246246-82-1
Benzyl {3-[({5-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}carbonyl)(methyl)amino]propyl}methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

1.2: 20 °C / Cooling with ice

1.3: 2 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / methanol / 10 h / 50 °C

2.2: pH 3

3.1: triethylamine; diphenyl phosphoryl azide / 3 h / Reflux

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C / Cooling with ice

4.2: 20 °C

With diphenyl phosphoryl azide; water; pivaloyl chloride; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;