N-[1-(2_,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

Base Information

• Chemical Name: N-[1-(2_,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
• CAS No.: 1092400-95-7
• Molecular Formula: C₁₆H₁₇Cl₂F₂N₃O₂
• Molecular Weight: 392.233

Synonyms:N-[1-(2_,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

Chemical Property of N-[1-(2_,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

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Technology Process of N-[1-(2_,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

There total 4 articles about N-[1-(2_,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride (141573-96-8) + 2-(2,4-dichloro-phenyl)-2-methoxy-1-methyl-ethylamine (1092400-98-0) → N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (1092400-95-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

2,4-dichloro-1-(1-methoxy-2-nitro-propyl)-benzene (1092400-97-9) → N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (1092400-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / RaNi / tetrahydrofuran; ethanol / 23 h / 20 °C / 37503.8 Torr

2: triethylamine / dichloromethane / 5 h / 0 - 20 °C

With hydrogen; triethylamine; RaNi; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

(E)-2,4-dichloro-1-(2-nitroprop-1-en-1-yl)benzene (52287-58-8) → N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (1092400-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / toluene / 1.5 h / 0 °C

2: hydrogen / RaNi / tetrahydrofuran; ethanol / 23 h / 20 °C / 37503.8 Torr

3: triethylamine / dichloromethane / 5 h / 0 - 20 °C

With methanol; hydrogen; triethylamine; RaNi; In tetrahydrofuran; ethanol; dichloromethane; toluene; 1: Michael addition;

upstream raw materials:

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride

2-(2,4-dichloro-phenyl)-2-methoxy-1-methyl-ethylamine

2,4-dichloro-1-(1-methoxy-2-nitro-propyl)-benzene

(E)-2,4-dichloro-1-(2-nitroprop-1-en-1-yl)benzene

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