2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole

Base Information

Chemical Name:2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole
CAS No.:294182-33-5
Molecular Formula:C₂₃H₁₅F₄NO₃S
Molecular Weight:461.437
Hs Code.:

Synonyms:2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole

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Chemical Property of 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole

Chemical Property:

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Technology Process of 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole

There total 3 articles about 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.9%

: 1774-47-6
trimethylsulfoxonium iodide

: 294182-12-0
2,2-difluoro-1-(2,4-difluorophenyl)-2-[1-(phenylsulfonyl)-3-indolyl]ethanone

: 294182-33-5
2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1h;

2,2-difluoro-1-(2,4-difluorophenyl)-2-[1-(phenylsulfonyl)-3-indolyl]ethanone; In tetrahydrofuran; dimethyl sulfoxide; at 0 ℃; for 1h;
DOI:10.1248/cpb.48.982

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 294182-33-5
2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 84.8 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2.1: NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

2.2: 54.9 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1248/cpb.48.982

Reference yield:

: 80360-14-1
3-iodo-1-phenylsulfonyl-1H-indole

: 294182-33-5
2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-1-(phenylsulfonyl)indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: Cu / dimethylsulfoxide / 1 h / 20 °C

1.2: 65.6 percent / dimethylsulfoxide / 15 h / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 84.8 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3.1: NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

3.2: 54.9 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; copper; sodium hydride; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1248/cpb.48.982