80360-14-1

Basic information

• Product Name: 3-IODO-1-(PHENYLSULFONYL)-1H-INDOLE
• Synonyms: 3-IODO-1-(PHENYLSULFONYL)-1H-INDOLE;3-Iodo-1-(phenylsulfonyl)indole;1-(benzenesulfonyl)-3-iodo-1H-indole
• CAS NO: 80360-14-1
• Molecular Formula: C₁₄H₁₀INO₂S
• Molecular Weight: 383.20417
• Mol File: 80360-14-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 125-129℃
• Boiling Point: 516.555 °C at 760 mmHg
• Flash Point: 266.203 °C
• Appearance: /
• Density: 1.733 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• Water Solubility: Insoluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-IODO-1-(PHENYLSULFONYL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-1-(PHENYLSULFONYL)-1H-INDOLE(80360-14-1)
• EPA Substance Registry System: 3-IODO-1-(PHENYLSULFONYL)-1H-INDOLE(80360-14-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 80360-14-1(Hazardous Substances Data)

Usage

Uses

It is used as pharmaceutical intermediate.

InChI:InChI=1/C14H10INO2S/c15-13-10-16(14-9-5-4-8-12(13)14)19(17,18)11-6-2-1-3-7-11/h1-10H

Upstream product

• 26340-47-6 3-Iodo-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 40899-71-6 1-benzenesulfonylindole 
• 129271-98-3 1-(phenylsulfonyl)-1H-indol-3-ylboronic acid 
• 120-72-9 indole 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 112890-09-2 phenyl β-(N-benzenesulfonylindolyl)iodonium chloride 

Downstream Products

• 86335-35-5 1-(phenylsulfonyl)indol-3-yl 3-carboxy-4-pyridyl ketone 
• 80360-13-0 3-lithio-1-(phenylsulfonyl)indole 
• 112890-10-5 N-benzenesulfonyl-3-methoxyindole 
• 80360-25-4 1-(phenylsulfonyl)-2-lithio-3-iodoindole 
• 80360-16-3 <1-(phenylsulfonyl)indol-3-yl>phenylmethanol 
• 183544-32-3 1-Benzenesulfonyl-3-pyridin-3-yl-1H-indole 
• 116325-17-8 N-benzenesulfonyl-1H-indole-3-carboxylic acid methyl ester 
• 145662-45-9 2-Bromo-3-iodo-1-(phenylsulfonyl)indole 
• 153827-71-5 ethyl 1-(benzenesulfonyl)-1H-3-iodoindole-2-carboxylate 
• 403642-46-6 (1-benzenesulfonyl-3-iodo-1H-indol-2-yl)-furan-2-yl-methanone 
• 180633-59-4 (1-benzenesulfonyl-1H-indol-3-yl)-(1-benzyloxymethyl-4-iodo-1H-imidazol-2-yl)-methanol 
• 153827-72-6 ethyl 4-iodo-1-(phenylsulfonyl)-3-indolecarboxylate 
• 135531-86-1 camalexin 
• 1038921-27-5 [4-(1-benzenesulfonyl-6-bromo-1H-indol-3-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-(1-benzenesulfonyl-1H-indol-3-yl)-methanone 

Relevant articles and documents

Mono-selective β-C-H arylation of: N -methylated amino acids and peptides promoted by the 2-(methylthio)aniline directing group

2-(Methylthio)aniline (MTA) directed C(sp3)-H functionalisations are efficient and straightforward protocols for the selective β-modification of N-methylated amino acids. The decreased reactivity of MTA in comparison with the 8-aminoquinoline (AQ) directing group allows for selective monoarylations in high yields without the formation of side products. The protocol is also suitable for the introduction of highly functionalised side chains onto the C-terminal alanines of dipeptides. The MTA directing group can easily be removed, providing free carboxylic acids as valuable building blocks.

Practical and efficient ipso-iodination of arylboronic acids via KF/I2 system

A facile and effective iododeboronation of variously substituted aryl and heteroarylboronic acids through activation and subsequent ipso-introduction of iodine is presented. The use of KF and I2 at 80 °C in 1,4-dioxane furnishes iodinated compounds in high yields.

A simple iodination protocol via in situ generated ICl using NaI/FeCl 3

A novel iodination of silyl-enol ethers using hitherto unexplored NaI/FeCl3 system is reported. The procedure has been extended to the iodination of aromatic and hetero aromatic compounds.