ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate
• CAS No.: 1260106-30-6
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.324
• Mol file: 1260106-30-6.mol

Synonyms:ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate

Chemical Property of ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate

There total 4 articles about ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-(ethoxycarbonyl)cyclohexyl)acetic acid (218779-77-2) + 1,1'-carbonyldiimidazole (530-62-1) → ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate (1260106-30-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

ethyl 4-(2-(tert-butoxy)-2-oxoethylidene)cyclohexanecarboxylate (218779-74-9) → ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate (1260106-30-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3: tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; hydrogen; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

Reference yield:

ethyl 4-oxocyclohexane-1-carboxylate (17159-79-4) → ethyl 4-(2-(1H-imidazol-1-yl)-2-oxoethyl)cyclohexanecarboxylate (1260106-30-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 18 h / 0 - 20 °C

2.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; ethyl acetate; mineral oil;

upstream raw materials:

2-(4-(ethoxycarbonyl)cyclohexyl)acetic acid

1,1'-carbonyldiimidazole

ethyl 4-(2-(tert-butoxy)-2-oxoethylidene)cyclohexanecarboxylate

ethyl 4-oxocyclohexane-1-carboxylate

Downstream raw materials:

ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

ethyl 4-((7-chloropyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

ethyl 4-((7-aminopyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate