ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate
CAS No.:1260106-31-7
Molecular Formula:C₁₆H₂₁N₃O₃
Molecular Weight:303.361
Hs Code.:

Synonyms:ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

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Chemical Property of ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

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Technology Process of ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

There total 6 articles about ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1820-80-0,916420-28-5
3-aminopyrazole

: 1260105-93-8
ethyl 4-(4-ethoxy-2,4-dioxobutyl)cyclohexanecarboxylate

: 1260106-31-7
ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Guidance literature:: at 100 ℃; for 18h; Neat (no solvent);

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1260106-31-7
ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 18 h / 0 - 20 °C

2.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: tetrahydrofuran / 18 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 18 h / -78 - 20 °C / Inert atmosphere

6.1: 18 h / 100 °C / Neat (no solvent)

With hydrogenchloride; hydrogen; sodium hydride; lithium hexamethyldisilazane; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; ethyl acetate; mineral oil;

Reference yield:

: 218779-74-9
ethyl 4-(2-(tert-butoxy)-2-oxoethylidene)cyclohexanecarboxylate

: 1260106-31-7
ethyl 4-((7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3.1: tetrahydrofuran / 18 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 18 h / -78 - 20 °C / Inert atmosphere

5.1: 18 h / 100 °C / Neat (no solvent)

With hydrogenchloride; hydrogen; lithium hexamethyldisilazane; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; ethyl acetate;