(2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester

Base Information

• Chemical Name: (2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester
• CAS No.: 950905-47-2
• Molecular Formula: C₃₅H₆₂O₆Si₂
• Molecular Weight: 635.045
• Mol file: 950905-47-2.mol

Synonyms:(2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester

Chemical Property of (2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester

There total 2 articles about (2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H17PO5 + (2R,3R,4R,5S,6R)-5,7-bis-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal (152328-93-3) → (2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester (950905-47-2)

Guidance literature:

C₉H₁₇PO₅; With diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -20 ℃; for 3h;

(2R,3R,4R,5S,6R)-5,7-bis-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1002/anie.200701065

Reference yield:

methyl 4-(diethylphosphono)crotonate (67629-62-3) + (2R,3R,4R,5S,6R)-5,7-bis-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal (152328-93-3) → (2E,4E)-(6S,7S,8R,9S,10R)-9,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6,8,10-trimethyl-undeca-2,4-dienoic acid methyl ester (950905-47-2)

Guidance literature:

methyl 4-(diethylphosphono)crotonate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -20 ℃; for 3h;

(2R,3R,4R,5S,6R)-5,7-bis-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1016/j.tet.2008.01.114

upstream raw materials:

(2R,3R,4R,5S,6R)-5,7-bis-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

methyl 4-(diethylphosphono)crotonate